Key Review Articles 

• Pasternak GW. Mu opioids and their receptors: evolution of a concept. Pharmacol Rev. 2013 Sep 27;65(4):1257-317

• Pasternak GW. Mu Opioid Pharmacology: 40 Years to the Promised Land. Adv Pharmacol. 2018;82:261-29

• Pasternak GW. Opioids and their receptors: Are we there yet? Neuropharmacology. 2014 Jan;76 Pt B:198-203

• Pasternak GW. Opiate pharmacology and relief of pain. J Clin Oncol. 2014 Jun 1;32(16):1655-61​

 

 

Key Scientific  Articles

• ​Lu Z. Truncated μ-Opioid Receptors With 6 Transmembrane Domains Are Essential for Opioid Analgesia. Anesth Analg. 2018 Mar;126(3):1050-1057

• Marrone GF. Truncated mu opioid GPCR variant involvement in opioid-dependent and opioid-independent pain modulatory systems within the CNS. Proc Natl Acad Sci U S A. 2016 Mar 29;113(13):3663-8

• Marrone GF. Tetrapeptide Endomorphin Analogs Require Both Full Length and Truncated Splice Variants of the Mu Opioid Receptor Gene Oprm1 for Analgesia. ACS Chem Neurosci. 2016 Dec 21;7(12):1717-1727

• Varadi A. Mitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit β-Arrestin-2. J Med Chem. 2016 Sep 22;59(18):8381-97

• Lu Z. Mediation of opioid analgesia by a truncated 6-transmembrane GPCR. J Clin Invest. 2015 Jul 1;125(7):2626-30

• Marrone GF. Radioligand Binding Assay for Exon 11-Associated Mu Opioid Receptor Target. Methods Mol Biol. 2015;1335:241-9

• Grinnell SG. Pharmacologic characterization in the rat of a potent analgesic lacking respiratory depression, IBNtxA. J Pharmacol Exp Ther. 2014 Sep;350(3):710-8

• Wieskopf JS. Broad-spectrum analgesic efficacy of IBNtxA is mediated by exon 11-associated splice variants of the mu-opioid receptor gene. Pain. 2014 Oct;155(10):2063-70

• Majumdar S. Synthesis and evaluation of aryl-naloxamide opiate analgesics targeting truncated exon 11-associated μ opioid receptor (MOR-1) splice variants. J Med Chem. 2012 Jul 26;55(14):6352-62

• Majumdar S. Truncated G protein-coupled mu opioid receptor MOR-1 splice variants are targets for highly potent opioid analgesics lacking side effects. Proc Natl Acad Sci U S A. 2011 Dec 6;108(49):19778-83

• Majumdar S. Generation of novel radiolabeled opiates through site-selective iodination. Bioorg Med Chem Lett. 2011 Jul 1;21(13):4001-4